{"id":22462,"date":"2019-10-29T16:28:50","date_gmt":"2019-10-29T16:28:50","guid":{"rendered":"https:\/\/www.simscale.com\/?page_id=22462"},"modified":"2023-03-24T08:34:40","modified_gmt":"2023-03-24T08:34:40","slug":"freezing-and-thawing","status":"publish","type":"page","link":"https:\/\/www.simscale.com\/simulations\/freezing-and-thawing\/","title":{"rendered":"Freezing and Thawing Unit"},"content":{"rendered":"<div class=\"hw-section hw-section--largeSpacing hw-genericPageTitle hw-genericPageTitle--background\">\n    <img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"341\" src=\"https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/cfd-airflow-in-freezing-and-thawing-room-1-1024x341.png\" class=\"hw-genericPageTitle__image-background\" alt=\"cfd airflow in freezing and thawing room\" srcset=\"https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/cfd-airflow-in-freezing-and-thawing-room-1-1024x341.png 1024w, https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/cfd-airflow-in-freezing-and-thawing-room-1-300x100.png 300w, https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/cfd-airflow-in-freezing-and-thawing-room-1-768x256.png 768w, https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/cfd-airflow-in-freezing-and-thawing-room-1.png 1500w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/>  \n    <div class=\"hw-contentWrap\">\n\n    \n\n\n<h1 class=\"wp-block-heading\">Freezing and Thawing Unit Design Optimization<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Cloud-based simulation to test, validate, and iterate designs easily<\/p>\n\n\n    <\/div>\n<\/div>\n\n\n\n\n\n<div   class=\"hw-section hw-section--normalSpacing hw-section--white\">\n\n        <div class=\"hw-contentWrap hw-contentWrap--narrowWidth hw-textLeft\">\n        \n        \n\n\n<p class=\"wp-block-paragraph\">For temperature-sensitive biopharmaceuticals, freezing and thawing rooms along with processes, equipment, and freeze-thaw chambers need to function at their best to avoid premature degradation, minimize the risk of microbial growth, and prolong shelf life. Controlled freezing and thawing rates are absolutely crucial to maintaining stability and quality of biotech and biopharma products, particularly where proteins are involved. Uncontrolled freezing and thawing can quickly alter a product\u2019s properties and even lead to product loss.<\/p>\n\n\n<\/div>\n<\/div>\n\n\n\n\n<div   class=\"hw-section hw-section--normalSpacing hw-section--noTopPadding hw-section--white\">\n\n        <div class=\"hw-contentWrap hw-contentWrap--normalWidth hw-textLeft\">\n        \n        \n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile is-style-imgDropShadow\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"513\" height=\"263\" src=\"https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/biopharmaceutical-employees-in-freezing-and-thawing-lab.jpg\" alt=\"biopharmaceutical employees in freezing and thawing lab\" class=\"wp-image-22652 size-full\" srcset=\"https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/biopharmaceutical-employees-in-freezing-and-thawing-lab.jpg 513w, https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/biopharmaceutical-employees-in-freezing-and-thawing-lab-300x154.jpg 300w\" sizes=\"auto, (max-width: 513px) 100vw, 513px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading\">Typical Freezing and Thawing Unit Applications<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Freezing and thawing units are used in a range of medical\/pharma applications including:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Pharmaceuticals and biopharma<\/li>\n\n\n\n<li>Biotechnology<\/li>\n\n\n\n<li>Biomedical research<\/li>\n\n\n\n<li>Biochemical processing<\/li>\n\n\n\n<li>Food production and gastronomy<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n<\/div>\n<\/div>\n\n\n\n\n<div   class=\"hw-section hw-section--normalSpacing hw-section--noTopPadding hw-section--white\">\n\n        <div class=\"hw-contentWrap hw-contentWrap--normalWidth hw-textLeft\">\n        \n        \n\n\n<div class=\"wp-block-media-text alignwide has-media-on-the-right is-stacked-on-mobile\"><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading\">Why is Online Simulation with SimScale Needed for Freezing and Thawing Unit Applications?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Where airflow and heat are concerned, simulation can be extremely useful in assessing and improving HVAC design. Using online simulation you quickly and easily visualize air behavior and identify areas of recirculation or unstable temperatures. Whether assessing an existing thawing unit or optimizing a design before construction, simulation offers engineers the results they need to ensure a stable and controlled environment for freezing and thawing processes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, the steep cost of hardware and steep learning curves of traditional, on-premises tools leave many designers to feel that simulation is not an option. SimScale has eliminated such traditional hurdles, thanks to the power of the cloud. With SimScale, engineers can:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Run multiple simulations in parallel for faster design optimization<\/li>\n\n\n\n<li>Get started quickly with an easy-to-learn interface<\/li>\n\n\n\n<li>Avoid manual updates, installation, or maintenance<\/li>\n\n\n\n<li>Simulate other CFD, FEA, or thermal applications<\/li>\n<\/ul>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"513\" height=\"263\" src=\"https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/Thawing-Room-Improved-Temp-Slice.jpg\" alt=\"Thawing Room Improved Temperature Slice from CFD simulation\" class=\"wp-image-22620 size-full\" srcset=\"https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/Thawing-Room-Improved-Temp-Slice.jpg 513w, https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/Thawing-Room-Improved-Temp-Slice-300x154.jpg 300w\" sizes=\"auto, (max-width: 513px) 100vw, 513px\" \/><\/figure><\/div>\n\n\n<\/div>\n<\/div>\n\n\n\n\n<div   class=\"hw-section hw-section--normalSpacing hw-section--lightBlue hw-section--cta\">\n\n        <div class=\"hw-contentWrap hw-contentWrap--normalWidth hw-textCenter\">\n        \n        \n\n\n<h2 class=\"wp-block-heading\">Want to try SimScale to optimize your own freezing and thawing unit design?<\/h2>\n\n\n\n<div class=\"hw-block hw-btnWrapper hw-btnWrapper--alignCenter \">\n    <a href=\"\/signup\/\" class=\"hw-btn  hw-btn--secondary  \"    data-collateral-name=\"\" data-collateral-type=\"\" data-collateral-campaign=\"\" data-type=\"\" >\n        Try SimScale Now    <\/a>\n<\/div>\n\n\n\n<\/div>\n<\/div>\n\n\n\n\n<div   class=\"hw-section hw-section--normalSpacing hw-section--white\">\n\n        <div class=\"hw-contentWrap hw-contentWrap--normalWidth hw-textLeft\">\n        \n        \n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile is-style-imgDropShadow\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"513\" height=\"263\" src=\"https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/cfd-healthcare-environment.jpg\" alt=\"cfd healthcare environment\" class=\"wp-image-22636 size-full\" srcset=\"https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/cfd-healthcare-environment.jpg 513w, https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/cfd-healthcare-environment-300x154.jpg 300w\" sizes=\"auto, (max-width: 513px) 100vw, 513px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading\">How to Better Control Freeze-Thaw Processes<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">In addition to adequate freezing and thawing equipment, an important contributor to freeze-thaw stability is proper HVAC design. Biopharma products can be extremely sensitive to temperature, air, and light exposure. Maintaining consistent freeze-thaw rates for all products within a cabinet relies on valid assessment of photostability, airflow, heat transfer, and average ambient temperatures. See how CFD can be used to assess airflow in healthcare environments in this webinar.<\/p>\n\n\n\n<div class=\"hw-block hw-btnWrapper hw-btnWrapper--alignLeft \">\n    <a href=\"https:\/\/www.simscale.com\/webinars-workshops\/cfd-airflow-hospital-healthcare\/\" class=\"hw-btn  hw-btn--secondary  \"     >\n        Watch Now    <\/a>\n<\/div>\n\n<\/div><\/div>\n\n\n<\/div>\n<\/div>\n\n\n\n\n<div   class=\"hw-section hw-section--normalSpacing hw-section--noTopPadding hw-section--noBottomPadding hw-section--white\">\n\n        <div class=\"hw-contentWrap hw-contentWrap--normalWidth hw-textLeft\">\n        \n        \n\n\n<div class=\"wp-block-media-text alignwide has-media-on-the-right is-stacked-on-mobile is-style-imgDropShadow\"><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading\">Ensuring Consistent Freezing and Thawing with CFD<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">When a client wanted to analyze the airflow within a thawing room where 20 frozen packs are thawed at -40 degrees C, SimScale created a simulation to enhance understanding of air changes and the local mean age of air within the design. See the initial results of the convective simulation performed and how the results led to improvements in the design in this presentation. View the slides here:<\/p>\n\n\n\n<div class=\"hw-block hw-btnWrapper hw-btnWrapper--alignLeft \">\n    <a href=\"https:\/\/www.slideshare.net\/SimScale\/freezethaw-application-cfd-analysis-of-thawing-room\" class=\"hw-btn  hw-btn--secondary  \"    data-collateral-name=\"\" data-collateral-type=\"\" data-collateral-campaign=\"\" data-type=\"\" >\n        See Presentation    <\/a>\n<\/div>\n\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"513\" height=\"263\" src=\"https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/cad-and-iso-results-of-thawing-room-simulation.jpg\" alt=\"cad and iso results of thawing room simulation\" class=\"wp-image-22641 size-full\" srcset=\"https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/cad-and-iso-results-of-thawing-room-simulation.jpg 513w, https:\/\/frontend-assets.simscale.com\/media\/2019\/11\/cad-and-iso-results-of-thawing-room-simulation-300x154.jpg 300w\" sizes=\"auto, (max-width: 513px) 100vw, 513px\" \/><\/figure><\/div>\n\n\n<\/div>\n<\/div>\n\n\n\n\n<div   class=\"hw-section hw-section--normalSpacing hw-section--white\">\n\n        <div class=\"hw-contentWrap hw-contentWrap--normalWidth hw-textLeft\">\n        \n        \n\n\n<h2 class=\"has-text-align-center wp-block-heading\">Example Freezing &amp; Thawing Room Projects<\/h2>\n\n\n\n\n<div id=\"projects_list\" class=\"\">\n                                        <input type=\"hidden\" name=\"project1\" id=\"project1\" value=\"https:\/\/www.simscale.com\/api\/v1\/projects\/dlynch\/thawing_room_-_demo\/\" \/>\n            <input type=\"hidden\" name=\"alt_image_src1\" id=\"alt_image_src1\" value=\"https:\/\/frontend-assets.simscale.com\/media\/2022\/10\/freezing-thawing-room.png\" \/>\n            <input type=\"hidden\" name=\"alt_image_alt1\" id=\"alt_image_alt1\" value=\"\" \/>\n        <\/div>\n\n<div class=\"hw-projectCardList\"><\/div>\n\n<script type=\"text\/x-handlebars-template\" id=\"projects-template\" nonce=\"394ff5650a888b64697799681354c936\">\n\n    <div class=\"com-projectCard\">\n        <a class=\"com-projectCard__wbLink\" href=\"\/workbench\/?pid={{projectIdExt}}\">\n            <svg class=\"com-projectCard__wbLinkIcon\" aria-hidden=\"true\" focusable=\"false\" data-prefix=\"fal\" data-icon=\"external-link-square\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" class=\"svg-inline--fa fa-external-link-square fa-w-14\"><path d=\"M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zm16 400c0 8.822-7.178 16-16 16H48c-8.822 0-16-7.178-16-16V80c0-8.822 7.178-16 16-16h352c8.822 0 16 7.178 16 16v352zM99.515 374.828c-4.686-4.686-4.686-12.284 0-16.971l195.15-195.15-.707-.707-89.958.342c-6.627 0-12-5.373-12-12v-9.999c0-6.628 5.372-12 12-12L340 128c6.627 0 12 5.372 12 12l-.343 136c0 6.627-5.373 12-12 12h-9.999c-6.627 0-12-5.373-12-12l.342-89.958-.707-.707-195.15 195.15c-4.686 4.686-12.284 4.686-16.971 0l-5.657-5.657z\" class=\"\"><\/path><\/svg>\n            Open in Workbench\n        <\/a>\n        <div {{#if walkMeOne}}id=\"walkMeProject\"{{\/if}}  class=\"com-projectCard__thumb\">\n            <a {{#if walkMeOne}}id=\"walkMeProjectClick\"{{\/if}} href=\"\/projects\/{{ ownerName }}\/{{ publicProjectName }}\/\">\n                <div class=\"com-projectCard__thumbOverlay\">\n                    <span class=\"com-projectCard__thumbOverlayText\">View Project<\/span>\n                <\/div>\n                <img loading=\"lazy\" class=\"com-projectCard__thumbImg\" data-project-src=\"{{ thumbnailUrl }}\" alt=\"{{ thumbnailAlt }}\" width=\"1440\" height=\"1080\"\/>\n            <\/a>\n        <\/div>\n        <div class=\"com-projectCard__body\">\n            <p class=\"com-projectCard__title\"><a href=\"\/projects\/{{ ownerName }}\/{{ publicProjectName }}\/\">{{ projectName }}<\/a><\/p>\n        <\/div>\n        <div class=\"com-projectCard__meta\">\n            <span class=\"com-projectStat com-projectStat--views\" data-toggle=\"tooltip\" data-placement=\"bottom\" title=\"Views\">{{ numberOfViews }}<\/span>\n            <span class=\"com-projectStat com-projectStat--shares\" data-toggle=\"tooltip\" data-placement=\"bottom\" title=\"Shares\">{{ numberOfCopies }}<\/span>\n            <span class=\"com-projectStat com-projectStat--simulationRun\" data-toggle=\"tooltip\" data-placement=\"bottom\" title=\"Results\">{{ numberOfSimulationRuns }}<\/span>\n        <\/div>\n    <\/div>\n\n<\/script>\n\n\n\n<div class=\"hw-block hw-btnWrapper hw-btnWrapper--alignCenter \">\n    <a href=\"https:\/\/www.simscale.com\/projects\/\" class=\"hw-btn  hw-btn--secondary  \"     >\n        See More Simulations    <\/a>\n<\/div>\n\n\n\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Freezing and Thawing Unit Design Optimization Cloud-based simulation to test, validate, and iterate designs easily...","protected":false},"author":95,"featured_media":0,"parent":22214,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/template-hw-blank.php","meta":{"_acf_changed":false,"_crdt_document":"","inline_featured_image":false,"footnotes":""},"class_list":["post-22462","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.simscale.com\/wp-json\/wp\/v2\/pages\/22462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.simscale.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.simscale.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.simscale.com\/wp-json\/wp\/v2\/users\/95"}],"replies":[{"embeddable":true,"href":"https:\/\/www.simscale.com\/wp-json\/wp\/v2\/comments?post=22462"}],"version-history":[{"count":0,"href":"https:\/\/www.simscale.com\/wp-json\/wp\/v2\/pages\/22462\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.simscale.com\/wp-json\/wp\/v2\/pages\/22214"}],"wp:attachment":[{"href":"https:\/\/www.simscale.com\/wp-json\/wp\/v2\/media?parent=22462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}